Endocrine Abstracts

Introduction: Pituitary apoplexy is a rare clinical syndrome secondary to abrupt haemorrhage or infarction of the pituitary gland. It complicates 2-12% of pituitary tumour, most commonly in the setting of non-functioning adenomas 1. We are reporting a case on the evolving apoplexy. A 28-year-old male with sudden onset stabbing type frontal headache at night. He described this as the worst headache in his life. CT scan of head at presentation showed a 1.9 m lesion in the pituit...

Introduction: Diabetes mellitus (DM) is a metabolic illness caused by insulin resistance or lack of it. Hypertension (HT) has been seen frequently in diabetic patients, and causes morbidity and mortality with its complications. Salusins are vasodilator and hypotensive peptids which function most in cardiovascular system. Apelin is an insulin-sensitive, vasoconstructive, positive inotropic-effective peptide. In this study, determining the levels of serum salusin-α, salusin...

Introduction: Diabetes mellitus is an important public health problem due to defects of the effect of the insulin or insulin deficiency, accompanied by chronic microvascular complications with diabetic nephropathy is characterised by proteinuria that the increasing number of patients progress to end stage renal disease. Many peptide hormone made in etiopathogenesis is situated, although adropin which discovered in recent years involves in glucose homeostasis, its relation to d...

Introduction: Radioiodine ablation with a whole-body scan is a well known therapeutic regimen for differentiated thyroid cancer. I-131 uptake in the breast has been described with a variety of normal and pathologic conditions such as gynecomastia, supernumerary breasts, fibroadenoma and lactational duct cyst or galactocele. Here we report a case with an incidental radioiodine uptake in breast who turned out to be breast cancer.Case report: A 70 years old...

Background: Graves’ disease is the commonest cause of hyperthyroidism. Although first line and definitive treatment options are clearly defined, management practices and the natural history in terms of outcomes of treatment in a large consecutive cohort of Graves’ disease has not been well characterised.Aims: To describe incidence, presentation, diagnosis, management strategies and medium term outcomes following anti-thyroid drug treatment, rad...

Introduction: Berardinelli Seip Congenital Lypodystrophy (BSCL) is a rare otosomal recessive disease characterized by major criteria which are lypoatrophy, acromegaloid features, hepatomegaly, hypertriglyceridemia, insulin resistance and minor citeria which are hypertrophic cardiomyopathy, psycomotor retardation, hirsutism, precocious puberty, long bone cysts, phlebomegaly. The presence of three major criteria or two major plus two minor criteria required for diagnosis of BSCL...

Introduction: Papillary thyroid carcinoma (PTC) patients with distant metastasis (DM) have variable clinical forms. PTC mostly metastasizes to the regional cervical lymph node. Metastasis rate is approximately 20–90% available when diagnosed. In addition, the overall incidence of DM is approximately 10%. DM are usually to the lungs, bone and brain. Furthermore rarely liver, pancreas, skeletal muscle, adrenal gland, ovaries, sphenoid sinuses and submandibular gland metasta...

Background: Severe hypocalcaemia is a life threatening metabolic emergency which must be identified and treated properly to prevent mortality.Objective: To highlight a rare finding of severe hypocalcaemia due to hypovitaminosis D in a Nigerian female on anti-tuberculous therapy.Case presentation: A 30-year-old Nigerian female who wears purdah presented to the medical emergency on account of perioral numbness, generalised muscle spa...

Introduction: Primary empty sella (PES) is often found incidentally during neuroradiological studies. Although pituitary function is usually normal in patients with PES, it could be associated with serious clinical conditions including different degrees of hypopituitarism. Post-operative empty sella (POES), the most common group, results from pituitary adenoma and their treatments. Our aim is to compare anterior pituitary functions and quality of life (QoL) with Short Form-36 ...

Proton pump inhibitor (PPI) drugs which are used safely to treat peptic ulcus disease since 2 decades, moderately increases gastrin hormone by decreasing gastric acid secretion. Preclinical studies show that gastrin itself, or drugs that increase gastrin levels such as PPIs, increase islet cell mass and improve glycaemic control. To the best of our knowledge one prospective and some retrospective studies claim that PPI medication in diabetic patients leads to an average decrea...